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T2-weighted axial MRI images (A) and corresponding binary maps showing the spatial distribution of spontaneous non-Gaussian R2* fluctuations (B) within tumor ROI’s (white voxels) for CALR HNSCC xenografts (central slices). C: Composite images of the corresponding tumor sections showing the distribution of Hoechst 33342 (perfusion, blue), pimonidazole adducts (hypoxia, green) and CD31 (endothelial cell expression, red).
