Table 2. Distribution of bow–tie scores b(m) in each stress response pathway.
| Bow–tie score b(m) | Ion homeostasis | Nutrient adaptation | Osmotic stress | Oxidative stress | Heat shock | Pheromone response |
|---|---|---|---|---|---|---|
| 0.5–1.0a | 5 Sho1/Pbs2, Hog1, Pbs2, Hog1/Msn2, Hog1 | 12 cAMP, EGO complex, Sit4, TORC1, Tap42/TORC1, ATP, Sit4/Tap42/TORC1, fructose 1,6-biphosphate, fructose 6-phosphate, glucose 6-phosphate | 6 Hog1/Msn2, Pbs2, Hog1, Sho1/Pbs2 | 8 Sit4, Msn2, Hyr1/Yap1/Ybp1, Yap1-Ox, Glc7/Reg1, Bmh2 | 5 cAMP, Cdc25, Cyr1/Srv2, Msn2, Bcy1 | 23 Cdc24/Far1/Ste4/Ste18, Ste4/Ste18, Bem1/GTP/Cdc42/Cdc24/Far1/Ste4/Ste18, Bem1/GTP/Cdc42/Cdc24/Far1/Ste4/Ste18/Ste20, GTP Gpa1/Ste4/Ste18,Ste5/Ste50/Ste11/Ste7/Kss1, Ste5/Ste50/Ste11/Ste7/Fus3, Ste12, Dig1/Dig2/Ste12, Kss1, a-factor/Ste3, alpha-factor/Ste2 |
| 0.2–0.5 | 3 | 28 | 14 | 30 | 19 | 7 |
| <0.2 | 81 | 133 | 67 | 71 | 41 | 2 |
| 0 | 529 | 325 | 245 | 268 | 190 | 162 |
| R2 coefficientb | 0.3165 | 0.8881 | 0.6902 | 0.5531 | 0.2243 | 0.8096 |
a
For molecules with very high bow–tie scores (0.5–1.0), the number of molecules in the map with bow–tie scores b(m) within this range are indicated above a list of molecules/complexes with these scores in each map. Molecules in different states (modification or localization) are represented without distinction. Instances separated with '/' indicate complexes.
b
R2 coefficient between bow–tie score and betweenness centrality.