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. 2016 Dec 22;2:16037. doi: 10.1038/npjsba.2016.37

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Heatmap representing the occurrence of 50 combinations of survival markers found by SURCOMED in breast cancer patients. The dendrogram on the top corresponds to the hierarchical clustering of patients based on these combinations. This figure illustrates that multiple survival signatures can be used to structure the population of patients and potentially to classify new patients in specific groups. The figure also shows that different combinations of survival markers can coexist in the same patient, either because they are associated with the same underlying biological mechanism or because multiple mechanisms are present in the same patient.