Table 3.
Final Body and Organ Weight
| Vehicle | Ang II | Ang II + ANA-12 | ANA-12 | |
|---|---|---|---|---|
| n | 5 | 7 | 6 | 4 |
| Body weight (g) | 480.0 ± 25.8 | 295.7 ± 22.5a | 390.0 ± 16.5b | 502.5 ± 15.6bc |
| Tibia (cm) | 5.88 ± 0.03 | 5.63 ± 0.08 | 5.73 ± 0.07 | 5.85 ± 0.07 |
| Heart weight (mg) | 1571.7 ± 115.1 | 1112.6 ± 78.4a | 1296.1 ± 61.8 | 1555.5 ± 14.6b |
| HW/BW (mg/g) | 3.3 ± 0.2 | 3.8 ± 0.1 | 3.3 ± 0.1 | 3.1 ± 0.1b |
| HW/TL (mg/cm) | 267.0 ± 18.8 | 197.0 ± 12.1a | 225.8 ± 9.2 | 266.0 ± 2.0b |
| Wet Lung (mg) | 2089.4 ± 89.4 | 1517.5 ± 103.1a | 1539.9 ± 41.5a | 1776.0 ± 25.2 |
| WL/BW (mg/g) | 4.5 ± 0.4 | 5.2 ± 0.3 | 4.0 ± 0.1b | 3.6 ± 0.1b |
| WL/TL (mg/cm) | 355.6 ± 16.5 | 268.6 ± 15.6a | 268.6 ± 6.2a | 303.7 ± 4.8 |
| Liver (g) | 17.7 ± 0.9 | 10.9 ± 0.8a | 12.2 ± 0.8a | 18.7 ± 0.8bc |
| LW/BW (mg/g) | 34.4 ± 1.2 | 37.0 ± 1.5 | 31.4 ± 1.8 | 37.2 ± 1.3 |
| LW/TL (g/cm) | 3.0 ± 0.2 | 1.9 ± 0.1a | 2.1 ± 0.1a | 3.2 ± 0.2bc |
| Left Kidney (mg) | 1695.5 ± 17.0 | 1373.6 ± 103.1 | 1651.6 ± 106.4 | 2008.0 ± 63.7 |
| Right Kidney (mg) | 1660.9 ± 24.0 | 1426.4 ± 94.3 | 1644.9 ± 89.6 | 2043.6 ± 72.9 |
BW = body weight; HW = heart weight; TL = tibia length; LW = liver weight;
a
p < 0.05 vs. Vehicle,
b
p < 0.05 vs. Ang II;
c
p < 0.05 vs.
Ang II + ANA-12; one-way ANOVA