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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Biomaterials. 2017 May 11;137:11–22. doi: 10.1016/j.biomaterials.2017.05.019

Figure 7.

Figure 7

Clinical observation of mice after treatment with Celludo. A. Change in body weight and clinical score upon administration of 3 doses of Celludo (180 mg PPT/kg; day 0, 4 and 8). Results presented as means± SEM, n= 3-4. Mice were clinically scored using an established scoring sheet (supplementary table 1). When the score in a single category reaches 5 or the cumulative score reaches 10 or greater for more than 24 h, the animal would be euthanized. Celludo administrations are indicated with arrows. B. Histopathological analysis of different tissues. One day post the final dose, tissues samples were collected, fixed in 10% formalin followed by paraffin embedding, and hematoxylin/eosin staining for histological analysis by a certified animal pathologist.