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. Author manuscript; available in PMC: 2017 Sep 2.
Published in final edited form as: Science. 2016 Sep 2;353(6303):1023–1027. doi: 10.1126/science.aaf4434

Fig. 2. Ligand development for enantioselective methylene C–H arylation.

Fig. 2

The yields were determined by 1H NMR analysis of the crude product using CH2Br2 as an internal standard. Enantiomeric ratios (er) were determined by chiral high-performance liquid chromatography. The absolute configurations of L13, L21, L35 and L40b were determined by X-ray crystallography (see supplementary material). HFIP, hexafluoro-2-propanol; Me, methyl group; Pr, propyl group; Bn, benzyl group; Ph, phenyl group.