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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Stroke. 2017 May 25;48(7):1941–1947. doi: 10.1161/STROKEAHA.117.017284

Figure 3.

Figure 3

Brain water content in stroke mice after intravenous injection of miR-15a/16-1 antagomir. C57BL/6J mice were treated with miR-15a/16-1 antagomir or antagomir control (n=8) and subjected to 1h MCAO and 72h reperfusion. Brains were dissected out and water content was measured by wet/dry weight method. Cerebral ischemia caused a significant increase in water content in the ipsilateral hemisphere compared to contralateral hemisphere. Systematic delivery of miR-15a/16-1 antagomir significantly reduced brain water content in MCAO mice compared to antagomir control group. Data are expressed as mean ± SEM. *p<0.05, **p<0.01 vs contralateral (non-ischemic) side, #p<0.05 vs MCAO + antagomir control group.