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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Stroke. 2017 May 25;48(7):1941–1947. doi: 10.1161/STROKEAHA.117.017284

Figure 6.

Figure 6

MiR-15a/16-1 antagomir improves sensorimotor functions of mice after cerebral ischemia. C57BL/6J mice were treated with miR-15a/16-1 antagomir or antagomir control (n=10) via tail vein injections and subjected to 1h MCAO followed by reperfusion, then tested every other day for 7 days. Ischemic mice were subjected to rotarod (A), foot fault (B), and adhesive tape removal tests (C, time to contact; D, time to remove) for examination of sensorimotor functions. In comparison with the antagomir control group, mice treated with miR-15a/16-1 antagomir showed improved duration of time on the rotarod, reduced percentage of foot fault steps, and improvement in the touch time and removal time of the adhesive tape compared to control ischemic mice at 3-7 days after MCAO. Data are expressed as mean ± SEM. *p<0.05, **p <0.01 vs MCAO + antagomir control group.