Table 2. Respiratory hospital admissions and postnatal dexamethasone exposure.
Respiratory hospital admission n = 88, 21% | |||
---|---|---|---|
N | Unadjusted proportions | Adjusted proportions 1 | |
Dexamethasone exposure | p-value<0.001 | ||
No | 292 | 0.15 | 0.15 |
Yes | 120 | 0.36 | 0.35 |
Difference (95% CI) | |||
Yes vs no | 0.20 (0.11, 0.30) | 0.20 (0.08, 0.31) | |
Timing of dexamethasone | Overall p-value: <0.001 |
Overall p-value: <0.001 |
|
None | 292 | 0.15 | 0.15 |
Early | 9 | 0.44 | 0.48 |
Late | 111 | 0.35 | 0.34 |
Differences (95% CI) | |||
Early vs none | 0.29 (-0.04, 0.62) | 0.33 (-0.01, 0.66) | |
Late vs none | 0.20 (0.10, 0.30) | 0.18 (0.07, 0.30) | |
No. of courses | Overall p-value: <0.001 |
Overall p-value: 0.001 |
|
0 course | 292 | 0.15 | 0.15 |
1 course | 76 | 0.34 | 0.33 |
2 courses | 31 | 0.39 | 0.38 |
3 courses | 13 | 0.38 | 0.40 |
Differences (95% CI) | |||
1 vs 0 courses | 0.19 (0.07, 0.30) | 0.18 (0.06, 0.30) | |
2 vs 0 courses | 0.23 (0.06, 0.41) | 0.23 (0.03, 0.43) | |
3 vs 0 courses | 0.23 (-0.04, 0.50) | 0.25 (-0.05, 0.55) | |
No. of days of exposure | Overall p-value: <0.001 |
Overall p-value: <0.001 |
|
0 | 292 | 0.15 | 0.15 |
1–6 | 24 | 0.21 | 0.22 |
7–12 | 44 | 0.41 | 0.39 |
>12 | 51 | 0.40 | 0.38 |
Differences (95% CI) | |||
1–6 vs 0 | 0.05 (-0.11, 0.22) | 0.07 (-0.10, 0.24) | |
7–12 vs 0 | 0.25 (0.10, 0.41) | 0.23 (0.08, 0.39) | |
>12 vs 0 | 0.24 (0.10, 0.38) | 0.23 (0.07, 0.39) |
1. Adjusted for sex, birthweight z-score, gestational age in weeks, smoking in pregnancy, oxygen dependency at 36 weeks, airleak, patent ductus arteriosus, pulmonary haemorrhage, major neonatal ultrasound abnormality, ventilation group and age at 24 month assessment using multiple logistic regression analysis.