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. Author manuscript; available in PMC: 2017 Jul 19.
Published in final edited form as: J Biomed Mater Res A. 2016 Jan 11;104(4):917–927. doi: 10.1002/jbm.a.35629

FIGURE 1.

FIGURE 1

Hydrolysis of siRNA-loaded polyplexes in aqueous solution. A: 1H-NMR analysis reveals HDG polymer hydrolysis at 24 and 48 h (arrows indicate either the appearance or disappearance of peaks over time due to hydrolysis). B: Structure of hydrolyzed HDG polymer (top) and quantification of polymer hydrolysis at 24 and 48 h (bottom). C: HDG-NPs (right) reduced in size after 24 h, indicating hydrolytically dependent nucleic acid release.