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HDG-NPs release nucleic acid cargo more efficiently than non-HDG-NPs. FRET signal is used to track nucleic acid release kinetics where loss of FRET is indicative of nucleic acid release. At 5:1 N:P ratio, HDG-NPs released ~40% more dsDNA at 24 h than non-HDG-NPs. Increasing the N:P ratio reduced the impact of the HDG chemistry, likely due to the presence of excess cationic charge.
