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Target gene silencing of the model gene luciferase by non-HDG- and HDG-NPs at N:P ratio of 5:1 (n=5). HDG-NPs exhibited enhanced siRNA potency at both 100 and 150 nM doses. All gene silencing data are normalized to an analogous scrambled siRNA control with the same carrier (HDG-NP and non-HDG-NP) and at each dose (100 and 150 nM). LF2K=Lipofectamine 2000.
