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. 2017 Jul 5;13(7):e1006882. doi: 10.1371/journal.pgen.1006882

Fig 2. EGFR regulates the luminal accumulation of Serp.

Fig 2

(A-F) Lateral views of embryos stained with Serp antibody at the indicated stages. From early stages Serp can be detected in the lumen (pink arrows) and in the apical membrane of tracheal cells (blue arrows). When EGFR is downregulated, Serp accumulation in the lumen decreases strongly with time, but remains detectable in the apical membrane (blue arrow in F). (G-I) Lateral views of embryos at the indicated stages carrying AbdGal4-UASGFP stained with Serp antibody (red or white) and GFP (green). Note the difference of Serp luminal accumulation in the Abd domain (marked by a white bracket) in the different EGFR mutant conditions. Scale bar 25 μm.