Fig. 1.

Anaplastic large cell lymphoma, ALK-negative, with DUSP22 rearrangement. a Photomicrograph demonstrating large, pleomorphic tumor cells, including a characteristic “hallmark” cell (H) with a horseshoe-shaped nucleus in the center of the image. b Fluorescence in situ hybridization image of two tumor cells (T) and one smaller, normal cell (N) using a break-apart probe to the DUSP22 gene region. The normal cell has two red-green fusion signals (f), representing two intact alleles. The tumor cells each have one fusion signal and one separated red-green signal (s), indicating a rearrangement of the DUSP22 gene region. This rearrangement has been associated with a favorable prognosis [29•]