Table 8.
Gene | Chr | N SNPs | Start position | End position | Theta-Fz energy | Theta-Fz ITPC | Delta-Pz energy | Delta-Pz ITPC | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
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Test-statistic | p-Value | Test-statistic | p-Value | Test-statistic | p-Value | Test-statistic | p-Value | |||||
DISC1 | 1 | 543 | 229,829,183 | 230,243,641 | 383.31 | 0.895 | 859.68 | 0.092 | 636.08 | 0.333 | 785.77 | 0.517 |
ARID5A | 2 | 46 | 96,566,190 | 96,582,098 | 88.07 | 0.147 | 118.18 | 0.036 | 10.09 | 0.980 | 29.57 | 0.605 |
DRD3 | 3 | 145 | 115,330,246 | 115,380,589 | 228.56 | 0.148 | 212.56 | 0.190 | 244.06 | 0.123 | 126.91 | 0.507 |
GSK3B | 3 | 214 | 121,028,235 | 121,295,203 | 138.55 | 0.700 | 222.08 | 0.408 | 663.98 | 0.014 | 109.84 | 0.835 |
MME | 3 | 131 | 156,280,129 | 156,384,212 | 101.98 | 0.650 | 67.87 | 0.910 | 76.65 | 0.884 | 140.82 | 0.378 |
FABP2 | 4 | 124 | 120,457,852 | 120,462,764 | 40.52 | 0.859 | 100.18 | 0.457 | 48.84 | 0.802 | 9.72 | 1.000 |
CNR1 | 6 | 137 | 88,906,303 | 88,911,775 | 99.68 | 0.719 | 71.53 | 0.892 | 84.87 | 0.821 | 156.15 | 0.345 |
ABCB1 | 7 | 228 | 86,970,883 | 87,180,500 | 444.58 | 0.058 | 137.49 | 0.791 | 229.71 | 0.401 | 105.44 | 0.898 |
CHRM2 | 7 | 293 | 136,203,938 | 136,352,311 | 97.41 | 0.999 | 186.34 | 0.817 | 252.84 | 0.586 | 485.29 | 0.116 |
GRM8 | 7 | 1338 | 125,865,887 | 126,679,664 | 1077.12 | 0.702 | 667.54 | 0.962 | 2544.71 | 0.042 | 2927.19 | 0.020 |
ANXA13 | 8 | 209 | 124,762,214 | 124,818,828 | 228.41 | 0.408 | 214.90 | 0.472 | 278.91 | 0.211 | 328.66 | 0.113 |
HTR7 | 10 | 233 | 92,490,555 | 92,607,651 | 235.46 | 0.435 | 386.14 | 0.182 | 344.19 | 0.175 | 84.82 | 0.911 |
BDNF | 11 | 96 | 27,633,017 | 27,699,872 | 193.04 | 0.078 | 115.37 | 0.306 | 33.08 | 0.933 | 52.04 | 0.787 |
DRD2 | 11 | 202 | 112,785,526 | 112,851,211 | 153.85 | 0.617 | 117.38 | 0.815 | 176.80 | 0.525 | 201.69 | 0.435 |
DRD4 | 11 | 60 | 627,304 | 630,703 | 105.67 | 0.132 | 45.88 | 0.625 | 29.95 | 0.830 | 68.39 | 0.338 |
MYEF2 | 15 | 12 | 46,218,920 | 46,257,850 | 4.75 | 0.465 | 27.23 | 0.099 | 7.46 | 0.429 | 12.46 | 0.289 |
CRHR1 | 17 | 47 | 41,217,448 | 41,268,973 | 272.32 | 0.001 | 46.54 | 0.384 | 11.79 | 0.911 | 53.22 | 0.311 |
KCNJ6 | 21 | 495 | 37,918,656 | 38,210,566 | 298.26 | 0.940 | 289.99 | 0.939 | 357.49 | 0.819 | 399.33 | 0.709 |
COMT | 22 | 146 | 18,309,308 | 18,336,530 | 259.82 | 0.078 | 316.40 | 0.032 | 89.53 | 0.812 | 61.00 | 0.954 |
Note: Chr is the chromosome on which each gene is located, NSNPs is the total number of SNPs included by VEGAS within the gene boundary. Its start and end position (using build hg37) are provided as well. The test-statistic for each phenotype is a chi-square statistic. Nominally significant associations (p < 0.05) are italicized. Only one association (bold face and italicized) surpassed the Bonferroni threshold of 2.64 × 10−3: CRHR1 and theta-Fz energy.