Fig. 4.

Full legend can be found on the next page.

a: Kaplan–Meier estimates and p-value of log-rank test for progression-free survival stratified according to randomisation arm (VC, VCE). b: Kaplan–Meier estimates and p-value of log-rank test for progression-free survival stratified according to localisation strata at randomisation: (i) Pure chiasmatic/Dodge II, (ii) chiasmatic-hypothalamic/Dodge III plus other midline structures, (iii) tumours outside the supratentorial midline. SM: Supratentorial midline. c: Kaplan–Meier estimates and p-value of log-rank test for progression-free survival stratified according to age group (strata at randomisation: <1 year, ≥1 and <8 years, ≥8 years) by randomisation arm (VC, VCE). d: For all patients without event by the time of response assessment at week 24: Kaplan–Meier estimates and p-value of log-rank test for progression-free survival measured from response assessment in week 24 stratified according to response status at week 24: (i) Complete response (CR), partial response (PR) or objective response (OR), (ii) stable disease (SD). e: Kaplan–Meier estimates and p-value of log-rank test for progression-free survival stratified according to indication to start treatment (diencephalic syndrome (DS), other).