Wild-type and Sdc1 null mice underwent laparotomy and hemorrhagic shock followed by resuscitation with either LR or FFP. After 3 hours Evans blue dye extravasation was measured in lungs. Data are expressed as mean ± SEM, n=8 per group with significance indicated by lines over the respective groups. FFP, fresh frozen plasma; LR, lactated Ringer’s; WT, wild type; KO, Sdc1 knockout; HS, hemorrhage shock.