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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Mol Imaging Biol. 2017 Jun;19(3):363–372. doi: 10.1007/s11307-017-1056-z

Table 1.

Biomedical nanoparticles developed from a wide variety of materials recently reported for theranostic applications. Nanoparticles with multiple functionalities are listed multiple times.

Noble metals Other metals Metal oxides Semiconductors Silica Carbon Polymers / Liposomes Proteins Other materials
Imaging MRI [40, 55, 157] [26, 28, 40, 88, 133, 158-161] [6-12, 26, 28, 40, 118, 121, 123, 133, 158-160, 162-168] [39-40] [55] [40] [126, 165] [82, 169-170]
PET/SPECT [16-17, 25, 29-30, 40, 101-102, 142, 171] [24, 26, 28, 40, 158-159, 172-174] [24, 26, 28, 40, 158-159, 162, 172-175] [18, 40] [20, 27, 34-35] [40, 109, 136] [21, 23, 99, 102, 106, 134-135] [32, 176] [22, 33, 131-132, 135, 145, 169]
CT [17, 30, 62, 65, 137-139, 142, 171] [80, 118-120] [18] [20, 27, 35] [62, 80, 138] [135, 143, 145]
Optical [36, 49-50, 52, 55-60, 146, 177] [36, 108, 117] [36, 78, 116] [19, 39] [34-35, 49-50, 52, 55-60, 156, 177] [109] [38, 43, 78, 105, 107, 126-127, 129, 146, 178] [116, 176] [145, 169]
Photo-acoustic [62-67] [79, 88] [78, 80, 90-91, 93] [72-73, 83-85] [92] [87, 151] [43, 62, 67-69, 71-73, 75, 78-80, 83-85, 93, 106] [76] [74, 77, 81-82, 86, 145]
Ultrasound [78, 165] [78, 126-127, 165]
Cerenkov [30, 101-102, 104, 171] [24] [24, 98, 103, 162, 175] [18-19] [100] [99, 102, 135] [98] [145, 179-180]
Therapy Drug delivery [66] [166] [92] [136] [105-106, 125, 127]
Gene/siRNA delivery [146] [108] [109] [99, 105, 107, 146, 178]
Immuno-therapy [101] [12] [130] [129-130] [181]
PTT/PDT [16, 63, 65, 67, 110-113, 146, 157] [88, 117, 174] [78, 80, 98, 116, 174] [73, 83-84] [100] [67, 73, 75, 78, 80, 83-84, 129, 146] [76, 98, 116] [82, 86, 143]
Radio-therapy [137-142] [133] [116, 118, 133] [135, 138] [116] [143]
Externally actuated [114-115] [118-121, 123]