Table 3.

Comparison of binding affinities of active Artemisinin based compounds with anti-malarial targets, plasmepsin-2 (2IGY) and falcipain-2 (3BPF)

Protein–ligand	Binding energy (kcal/mol)	Protein–ligand	Binding energy (kcal/mol)
2IGY_A53	−6.8	3BPF_A53	−7.9
2IGY_A54	−6.9	3BPF_A54	−7.8
2IGY_A62	−6.7	3BPF_A62	−7.2
2IGY_A54-N1	−6.8	3BPF_A54-N1	−7.7
2IGY_Artemether	−6.5	3BPF_Artemether	−6.6
2IGY_Artemisinin	−6.6	3BPF_Artemisinin	−6.8
2IGY_DHA	−6.6	3BPF_DHA	−6.6
2IGY_N11	−7.7	3BPF_N11	−9.6
2IGY_N2	−7.7	3BPF_N2	−8.6
2IGY_N8	−8.2	3BPF_N8	−9.1
2IGY_N30	−9.2	3BPF_N30	−10.8
2IGY_N33	−8.2	3BPF_N33	−8.5
2IGY_N39	−8.6	3BPF_N39	−9.5
2IGY_N43	−8.1	3BPF_N43	−9.6
2IGY_N44	−7.3	3BPF_N44	−8.2
2IGY_N45	−7.9	3BPF_N45	−8.7
2IGY_N47	−7.6	3BPF_N47	−8.1
2IGY_Deoxyartemisinin	−6.6	3BPF_Deoxyartemisinin	−7
2IGY_12F	−10.3	3BPF_12F	−11.4