Table 1.
Selected human and murine chemokines and their receptorsa.
| Chemokine | Other names | Gene | Receptors | Key function | |
|---|---|---|---|---|---|
| Human | Mouse | ||||
| CCL2 | MCP-1 JE (mouse) | CCL2 | Ccl2 | CCR2 | Inflammatory monocyte trafficking |
| CCL3 | MIP-1α | CCL3 | Ccl3 | CCR1, CCR5 | Macrophage and NK cell migration, T cell-DC interactions |
| CCL4 | MIP-1β | CCL4 | Ccl4 | CCR5 | |
| CCL5 | RANTES | CCL5 | Ccl5 | CCR1, CCR3, CCR5 | |
| CCL11 | Eotaxin | CCL11 | Ccl11 | CCR3, CCR5 | Eosinophil and basophil migration |
| CCL20 | MIP-3α | CCL20 | Ccl20 | CCR6 | Th17 responses, B cell and DC homing |
| CXCL1 | GROα Gm1960 (mouse) | CXCL1 | Cxcl3 | CXCR2 | Neutrophil trafficking |
| CXCL3 | GROγ KC (mouse) | CXCL3 | Cxcl1 | CXCR2 | |
| CXCL4 | PF4 | PF4 | – | CXCR3-B | Procoagulant |
| CXCL4L1 | PF4V1 | PF4V1 | Pf4 | CXCR3-B | |
| CXCL8 | IL-8 | IL-8 | – | CXCR1, CXCR2 | Neutrophil trafficking |
| CXCL9 | MIG | CXCL9 | Cxcl9 | CXCR3 | T cell and NK cell trafficking |
| CXCL10 | IP-10 | CXCL10 | Cxcl10 | CXCR3 | |