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. 2017 Jul 19;7:5901. doi: 10.1038/s41598-017-06142-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of CSLPHNPs. Scanning electron microscopy image of (A) PLGA cores and (B) CSLPHNPs; 20,000/22,000X magnification (Scale bar: 1 µm). (C) Dynamic light scattering (DLS) measurement of the size distribution of PLGA cores-dash line, CSLPHNPs-solid line. (D) Temporal release of FTY720 (black squares) and docetaxel (white circles) at pH 5 was measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Points, mean of three experiments performed in triplicate. Bars, SE.