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. 2017 Jul 19;7:5818. doi: 10.1038/s41598-017-06088-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GSK’872 and combinative intervention attenuated ischemic brain injury and neurological deficits induced by MCAO in mice. (a) Ischemic areas were visualized by TTC staining at 48 h after MCAO (n = 3 per group). Normal tissue stained rose-pink, whereas infarct area appeared white. (b) Infarct volume was quantified by Image-Pro plus 6.0 software. (c) Neurological deficits were evaluated by mNSS at 6, 24, 48 and 72 h after MCAO (n = 9 per group). Data are presented as the mean ± SD. *p < 0.05, **p < 0.01 vs. control group.