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. 2017 Jul 19;7:5818. doi: 10.1038/s41598-017-06088-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RIP3 siRNA alleviated cell death and decreased the protein level of HIF-1α post OGD in HT-22 cells. (a) The viability of transfected HT-22 cells was detected by MTT assay after 9 h of reoxygenation. (b) The alterations of cell death with different siRNA transfections were analyzed by flow cytometry. (c) The protein expressions of HIF-1α, RIP3, MLKL and phosphorylated MLKL were determined by Western Blotting assay, normalized to β-actin levels. Control siRNA represented nontargeting siRNA transfection and pho-MLKL was the abbreviation of the phosphorylated MLKL. **p < 0.01 vs. Control siRNA group. Also see Supplementary Figure S4.