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. 2017 Jul 19;7:5921. doi: 10.1038/s41598-017-05656-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bile acid profiles for the liver, serum, and feces of male C57BL/6 mice orally gavaged with sesame oil vehicle or TCDD (3–30 µg/kg) every 4 days for 28 days. Individual bile acid species were quantified using high resolution accurate mass liquid chromatography mass spectrometry and expressed as fold changes relative to vehicle controls. Red and blue indicate increased or decreased levels, respectively, while grey indicates ‘not detected’. ‘∞’ indicates an incalculable increase as the bile acid was detected in treated animals but not controls. Statistical significance (*p ≤ 0.05) was determined using one-way ANOVA analysis followed by Dunnett’s post-hoc test (liver) or a Student’s t-test (serum) performed in SAS 9.3. Fecal pellets were collected from two cages of co-housed mice for each treatment group (n = 2) and therefore statistical analysis was not performed.