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. 2017 Jul 19;7:5806. doi: 10.1038/s41598-017-05296-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-metastatic study of BBM-NPs in C57BL/6 mice melanoma model. (a)To achieve a moderately cytotoxic dose of BBM-NPs to the tumor, initially we have developed a subcutaneous tumor model (detailed protocol in materials and methods) and injected BBM-NPs at a dose of 30 mg/kg body weight on 1^st, 3^rd and 5^th day intraperitoneally and finally sacrificed on 12^th day. (i) Tumor volume in mm³. (ii) The representative picture of the tumor. (iii) Tumor weight measured in grams. Data represented above are as mean ± SEM, n = 3. (b) To evaluate the efficacy of BBM to hematogenous lung metastasis, we have injected B16F10 cells (2 × 10⁵) to the tail vein of C57BL/6 mice (n = 3). Next, we have injected Native BBM and BBM-NPs (30 mg/kg body weight) on 0 and 2^nd day of cells injection. After 45 days, the mice were sacrificed and lungs were collected and weighed. (i) The representative picture of the lungs. (ii) The weight of lungs in grams. The datas are represented as mean ± SEM, *p < 0.05, **p < 0.005 for BBM-NPs treated mice vs. Native BBM and vs. control. Arrow indicates the tumor nodule.