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. 2017 Jul 20;9:231. doi: 10.3389/fnagi.2017.00231

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Copyright © 2017 Ponomarenko, Chadaeva, Rasskazov, Sharypova, Kashina, Drachkova, Zhechev, Ponomarenko, Savinkova and Kolchanov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The kinetics of binding to and bending of the ODN identical to the selected SNP marker rs1800202. (A) The ancestral allele, ODN 5′-cgcggcgctcTATATAAgtgggcagt-3′. (B) The minor allele, ODN 5′-cgcggcgctcTATAgAAgtgggcagt-3′. ODN concentration was 0.1 μM. TBP concentration was varied between 0.1 and 1.0 μM as indicated near the corresponding curve of the time series. K_D values, (A) 1 nM and (B) 19 nM, were obtained as the output of the Dynafit software (Biokin, USA) after the corresponding time-series data were inputted into this software.