Table 2.

Known and candidate SNP markers of sporadic AD near TBP-binding sites of promoters of the human genes associated with the hereditary immune system-related diseases.

Gene (OMIM ID)	dbSNP] rel. 147 or see [Ref]	5′ flank	wt mut	3′ flank	K D , nM					Known diseases (known SNP markers) or hypothetical disease (candidate SNP markers)	(Ref) or (this work)
					wt mut	Δ	Z	α	ρ
CETP (118470)	DEL-51(18 bp) Plengpanich et al., 2011	cgtgggggct	18bp −	gggctccagg	4 7	↓	7	10−6	A	Hyperalphalipoproteinemia that prevents atherosclerosis and (hypothetically) higher risk of AD (rs1800775 of CETP [down] increases risk of AD)	Plengpanich et al., 2011 (this work), Rodriguez et al., 2006
	rs17231520	ggggctgggc	g a	gacatacata	4 2	↑	10	10−6	A	(hypothetically) lower risk of AD
	rs569033466	atacatatac	g a	ggctccaggc	4 3	↑	4	10−3	B
	rs757176551	catatacggg	c g	tccaggctga	4 2	↑	10	10−6	A
MMP12 (601046)	rs2276109	gatatcaact	a g	tgagtcactc	11 14	↓	3	10−2	C	Lower risk of psoriasis, systemic sclerosis, and asthma	Ponomarenko et al., 2015, (this work), Walker et al., 2006; Ito et al., 2007
	rs572527200	gatgatatca	a g	ctatgagtca	11 14	↓	3	10−2	C	(hypothetically), lower risk of AD (MMP12 excess provokes inflammatory response whose result is neuronal cell loss)
MBL2 (154545)	rs72661131	tctatttcta	t c	atagcctgca	2 4	↓	12	10−6	A	Variable immunodeficiency, preeclampsia, stroke	Ponomarenko et al., 2015, (this work), Sjolander et al., 2013
	rs562962093	atctatttct	a g	tatagcctgc	2 5	↓	15	10−6	A	(hypothetically) higher risk of AD
	rs567653539	tttctatata	g a	cctgcaccca	2 1	↑	12	10−6	A	(hypothetically) lower risk of AD
SOD1 (147450)	rs7277748	ggtctggcct	a g	taaagtagtc	2 7	↓	17	10−6	A	Amyotrophic lateral sclerosis, (hypothetically), higher risks of Aβ oligomerization and memory loss in AD	Niemann et al., 2007, (this work), Murakami et al., 2011