Table 1.

Results for the successfully replicated SNPs in discovery, replication and combined sample

SNP ID	Chrom	Position	Closest gene	Allele ½	EAF	Discovery (n = 38,292)			Replication EU (n = 47,227)			Combined EU (n = 85,519)
						Beta	SE	p-value	Beta	SE	p-value	Beta	SE	p-value
Whole body lean mass
rs2943656	2	226830162	IRSI	A/G	0.38	−0.17	0.03	2.5 × 10−7	−0.13	0.03	8.0 × 10−6	−0.14	0.02	1.5 × 10−11
rs9991501	4	88477507	HSD17B11	T/C	0.04	−0.61	0.01	2.9 × 10−8	−0.26	0.08	1.9 × 10−3	−0.39	0.07	5.8 × 10−9
rs2287926	5	82851164	VCAN	A/G	0.12	0.24	0.05	8.6 × 10−7	0.15	0.04	8.5 × 10−4	0.19	0.03	7.5 × 10−9
rs4842924	15	82378611	ADAMTSL3	T/C	0.52	−0.17	0.03	1.4 × 10−7	−0.08	0.03	3.9 × 10−3	−0.12	0.02	1.4 × 10−8
rs9936385	16	52376670	FTO	T/C	0.61	−0.17	0.03	1.1 × 10−6	−0.11	0.03	1.6 × 10−4	−0.14	0.02	1.4 × 10−9

SNP ID	Chrom	Position	Closest gene	Allele ½	EAF	Discovery (n = 28,330)			Replication EU (n = 42,360)			Combined EU (n = 70,690)
						Beta	SE	p -value	Beta	SE	p -value	Beta	SE	p -value
Appendicular lean mass
rs2943656	2	226830162	IRS1	A/G	0.38	−0.10	0.02	1.1 × 10−6	−0.06	0.01	2.2 × 10−5	−0.07	0.01	2.9 × 10−10
rs2287926	5	82851164	VCAN	A/G	0.13	0.14	0.03	8.1 × 10−7	0.08	0.02	3.5 × 10−4	0.10	0.02	4.5 × 10−9
rs4842924	15	82378611	ADAMTSL3	T/C	0.52	−0.09	0.02	1.2 × 10−6	−0.05	0.02	1.6 × 10−3	−0.06	0.01	5.0 × 10−8

All results reflect analyses in participants of European ancestry

No significant heterogeneity was observed at α = 0.00625 (0.05/8)

Only mild heterogeneity was indicated in two associations for whole body lean mass when using an uncorrected threshold of α = 0.05, FTO/rs9936385 (p = 0.018, I ² = 34%) and HSD17B11/ rs9991501 (p = 0.04, I ² = 31%)

All results were adjusted for the following covariates: sex, age, height and fat mass (kg)