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. 2017 Jul 19;7:5805. doi: 10.1038/s41598-017-06020-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Performance comparison of the three network growing tools in terms of KEGG pathways and GO BP. (a) Rate of overlapping KEGG pathways before and after network growing relative to pathways of the 153 and 1463 known IHFs. (b) Rate of overlapping GO BP of the grown genes relative to GO BP of the 153 and 1463 known IHFs. (c) Pairwise analysis of KEGG pathways from the grown genes in the network growing tools and KEGG pathways of the positive sets (1463 IHFs) (d) Pairwise analysis of GO BP from the grown genes in the network growing tools and GO BP of the positive sets (1463 IHFs).