Table 3. Metabolic Parameters at baseline in Subclinical Hypothyroid (SCH) subjects and Euthyroid (EU) controls and at Pre-and-Post Rx with thyroxin in SCH subjects.
| Metabolic Parameters at baseline b/w SCH and EU groups |
Changes of Metabolic Parameters at pre-and-post thyroxin Rx in SCH |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Studies # | Sample size (SCH/EU) | WMD (95%CI) | I2 Statistic %; P | P value | # of studies | Sample size SCH (Pre-Rx/Post-Rx) | WMD (95%CI) | I2 Statistic %; P | P value | |
| TC | 11 | 324/321 | 0.71 [0.23, 1.19] |
87%; 0.00001 | 0.004 | 10 | 299/295 | −0.53 [−0.97, −0.09] |
85%; 0.00001 | 0.02 |
| TG | 11 | 324/321 | 0.51 [0.13, 0.90] |
81%; 0.00001 | 0.009 | 10 | 299/295 | −0.55 [−0.96, −0.13] |
83%; 0.00001 | 0.01 |
| LDL | 12 | 380/367 | 0.63 [0.30, 0.95] |
78%; 0.00001 | 0.0001 | 10 | 299/295 | −0.57 [−0.98, −0.15] |
83%; 0.00001 | 0.007 |
| HDL | 12 | 380/367 | 0.02 [−0.24, 0.27] |
65%; 0.0009 | 0.90 | 8 | 224/220 | 0.03 [−0.16, 0.22] |
0%; 0.57 | 0.75 |
| SBP | 8 | 265/258 | 6.16 [1.88, 10.45] |
62%; 0.009 | 0.005 | 6 | 209/205 | −0.33 [−0.62, −0.05] |
52%; 0.07 | 0.02 |
| DBP | 8 | 265/258 | 0.43 [0.11, 0.76] |
69%; 0.002 | 0.009 | 6 | 209/205 | −0.38 [−0.68, −0.08] |
56%; 0.04 | 0.01 |
TC = Total cholesterol, TG = Triglycerides, LDL = Low density lipoprotein, HDL = High density lipoprotein, SBP = Systolic Blood Pressure, DBP = Diastolic Blood Pressure.