Table 1. Baseline clinical characteristics (n = 1,307).
| Homocysteine level | < 12.0 µmol/L | ≥ 12.0 µmol/L | P value |
|---|---|---|---|
| (n = 883) | (n = 424) | ||
| Age ± SD (years) | 61.1 ± 12 | 65.2 ± 12 | < 0.001 |
| Woman, n (%) | 169 (19.1) | 73 (17.2) | 0.447 |
| Diabetes mellitus, n (%) | 246 (27.9) | 153 (36.1) | 0.003 |
| Hypertension, n (%) | 497 (56.3) | 270 (63.7) | 0.033 |
| Currently smoking, n (%) | 397 (45.0) | 170 (40.1) | 0.107 |
| Hyperlipidemia, n (%) | 462 (51.6) | 203 (46.1) | 0.063 |
| Hx of PCI, n (%) | 99 (11.2) | 60 (14.2) | 0.148 |
| Hx of stroke, n (%) | 42 (4.8) | 33 (7.8) | 0.031 |
| Hx of MI, n (%) | 468 (53.0) | 231 (54.5) | 0.636 |
| Homocysteine, mean ± SD, µmol/l | 8.7 ± 2.0 | 16.4 ± 8.5 | < 0.001 |
| Serum creatinine, mean ± SD, mg/dL | 1.01 ± 0.23 | 1.12 ± 0.24 | < 0.001 |
| eGFR, mean ± SD, ml/min/1.73 m2 | 74.9 ± 26.8 | 65.8 ± 20.1 | < 0.001 |
| Stable angina, n (%) | 486 (55.0) | 242 (57.1) | 0.488 |
| ACS, n (%) | 397 (45.0) | 182 (42.9) | 0.521 |
| LVEF < 40%, n (%) | 76 (9.3) | 70 (17.9) | < 0.001 |
| Cardiogenic shock, n (%) | 46 (5.2) | 27 (6.4) | 0.440 |
| Multivessel disease, n (%) | 578 (65.5) | 295 (69.6) | 0.149 |
ACS: acute coronary syndrome; eGFR: estimated glomerular filtration rate, calculated by the Modification of Diet in Renal Disease (MDRD) equation. Hx: history of occurrence 6 months or longer before the study; LVEF: left ventricular ejection fraction, measured by angiography; MI: myocardial infarction; PCI: percutaneous coronary intervention; SD: standard deviation.