Table 3. Age- and sex-adjusted and multivariable-adjusted HR for the development of cardiovascular disease according to non-HDL-C levels by CKD status.

	CKD (−)				CKD (+)
	Serum non-HDL-C levels, mg/dL				Serum non-HDL-C levels, mg/dL
	< 150	150–189	≥ 190	p for trend	< 150	150–189	≥ 190	p for trend
	(n = 1,089)	(n = 753)	(n = 431)		(n = 141)	(n = 118)	(n = 98)
Cardiovascular disease
No. of events	145	100	74		38	32	33
Age- and sex-adjusted HR (95% CI)	1.00	1.00 (0.78–1.30)	1.30 (0.97–1.73)	0.1	1.00	1.14 (0.70–1.85)	1.48 (0.91–2.41)	0.1
Multivariable-adjusted HR (95% CI) a	1.00	1.00 (0.77–1.31)	1.33 (0.98–1.81)	0.1	1.00	1.17 (0.70–1.97)	1.52 (0.89–2.58)	0.1
Coronary heart disease
No. of events	53	45	36		16	17	19
Age- and sex-adjusted HR (95% CI)	1.00	1.32 (0.88–1.97)	2.04 (1.32–3.16)	0.002	1.00	1.69 (0.84–3.41)	2.36 (1.18–4.72)	0.02
Multivariable-adjusted HR (95% CI)a	1.00	1.31 (0.86–1.99)	2.12 (1.33–3.38)	0.002	1.00	2.23 (1.04–4.77)	3.20 (1.46–7.03)	0.004
Stroke
Ischemic stroke
No. of events	76	54	34		16	19	13
Age- and sex-adjusted HR (95% CI)	1.00	1.01 (0.71–1.44)	1.06 (0.70–1.60)	0.8	1.00	1.38 (0.70–2.73)	1.14 (0.53–2.42)	0.7
Multivariable-adjusted HR (95% CI)a	1.00	1.03 (0.72–1.48)	1.06 (0.68–1.65)	0.8	1.00	1.28 (0.60–2.73)	1.11 (0.49–2.54)	0.8
Hemorrhagic stroke
No. of events	27	14	9		10	1	4
Age- and sex-adjusted HR (95% CI)	1.00	0.70 (0.37–1.34)	0.75 (0.35–1.62)	0.3	1.00	0.14 (0.02–1.08)	0.68 (0.20–2.28)	0.3
Multivariable-adjusted HR (95% CI)a	1.00	0.67 (0.35–1.31)	0.74 (0.33–1.66)	0.3	1.00	0.17 (0.02–1.45)	0.72 (0.19–2.73)	0.5

^aAdjusted for age, sex, systolic blood pressure, antihypertensive medication, diabetes, body mass index, serum albumin, serum high-sensitivity C-reactive protein, electrocardiogram abnormalities, smoking habits, alcohol intake, and regular exercise.

Abbreviations: CKD, chronic kidney disease; non-HDL-C, non-high-density lipoprotein cholesterol; HR, hazard ratio; CI, confidence interval.