Supplementary Table 1. Age- and sex-adjusted and multivariable-adjusted HR for the development of cardiovascular disease according to non-HDL-C levels by CKD status (CKD defined by eGFR using the CKD-EPI equation).
| CKD (−) |
CKD (+) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Serum non-HDL-C levels, mg/dL |
Serum non-HDL-C levels, mg/dL |
|||||||
| < 150 | 150–189 | ≥ 190 | p for trend | < 150 | 150–189 | ≥ 190 | p for trend | |
| (n = 1,150) | (n = 809) | (n = 487) | (n = 80) | (n = 62) | (n = 42) | |||
| Cardiovascular disease | ||||||||
| No. of events | 163 | 119 | 89 | 20 | 13 | 18 | ||
| Age- and sex-adjusted HR (95% CI) | 1.00 | 1.05 (0.83–1.33) | 1.29 (0.99–1.69) | 0.08 | 1.00 | 0.94 (0.46–1.92) | 2.10 (1.08–4.08) | 0.04 |
| Multivariable-adjusted HR (95% CI)a | 1.00 | 1.05 (0.82–1.35) | 1.32 (0.99–1.75) | 0.08 | 1.00 | 0.90 (0.40–2.01) | 2.62 (1.23–5.61) | 0.02 |
| Coronary heart disease | ||||||||
| No. of events | 63 | 54 | 43 | 6 | 8 | 12 | ||
| Age- and sex-adjusted HR (95% CI) | 1.00 | 1.33 (0.92–1.92) | 1.92 (1.29–2.87) | 0.002 | 1.00 | 2.09 (0.70–6.27) | 4.75 (1.71–13.23) | 0.002 |
| Multivariable-adjusted HR (95% CI)a | 1.00 | 1.38 (0.94–2.03) | 2.03 (1.32–3.13) | 0.001 | 1.00 | 2.59 (0.75–8.96) | 5.36 (1.62–17.71) | 0.005 |
| Stroke | ||||||||
| Ischemic stroke | ||||||||
| No. of events | 84 | 66 | 41 | 8 | 7 | 6 | ||
| Age- and sex-adjusted HR (95% CI) | 1.00 | 1.08 (0.78–1.49) | 1.04 (0.71–1.53) | 0.8 | 1.00 | 1.22 (0.43–3.45) | 1.63 (0.55–4.83) | 0.4 |
| Multivariable-adjusted HR (95% CI)a | 1.00 | 1.09 (0.77–1.53) | 1.05 (0.70–1.58) | 0.8 | 1.00 | 0.89 (0.26–3.08) | 2.72 (0.72–10.28) | 0.2 |
| Hemorrhagic stroke | ||||||||
| No. of events | 30 | 14 | 10 | 7 | 1 | 3 | ||
| Age- and sex-adjusted HR (95% CI) | 1.00 | 0.62 (0.33–1.19) | 0.71 (0.34–1.48) | 0.2 | 1.00 | 0.21 (0.03–1.79) | 0.97 (0.24–3.96) | 0.7 |
| Multivariable-adjusted HR (95% CI)a | 1.00 | 0.60 (0.31–1.17) | 0.69 (0.32–1.49) | 0.2 | 1.00 | 0.23 (0.02–2.87) | 1.21 (0.25–5.86) | 0.9 |
a
Adjusted for age, sex, systolic blood pressure, antihypertensive medication, diabetes, body mass index, serum albumin, serum high-sensitivity C-reactive protein, electrocardiogram abnormalities, smoking habits, alcohol intake, and regular exercise.
Abbreviations: CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; non-HDL-C, non-high-density lipoprotein cholesterol; HR, hazard ratio.