Table 1c. Apolipoprotein, lipoprotein, and lipase levels and synthesis and resorption markers before and 12 weeks after the drug intervention.
Drug intervention | statin group (n = 25) | F/E group (n = 25) | |
---|---|---|---|
apoB48 (µg/mL) | before | 5.5 ± 3.7 | 6.1 ± 4.7 |
after | 5.7 ± 2.9 | 3.4 ± 2.8**†† | |
apoB (mg/dL) | before | 91.0 ± 16.6 | 98.2 ± 18.3 |
after | 88.9 ± 14.5 | 84.9 ± 18.2** | |
apoA1 (mg/dL) | before | 148.2 ± 30.4 | 152.7 ± 24.1 |
after | 150.2 ± 28.8 | 164.4 ± 21.5* | |
Lp(a) (mg/dL) | before | 14.9 ± 13.9 | 31.1 ± 33.7 |
after | 16.4 ± 13.9 | 24.5 ± 23.2* | |
LPL (ng/mL) | before | 94.8 ± 37.7 | 87.1 ± 31.3 |
after | 118.6 ± 154.6 | 74.9 ± 26.0* | |
sitosterol (µg/mL) | before | 3.6 ± 2.5 | 2.8 ± 0.8 |
after | 3.9 ± 3.0 | 0.8 ± 0.4**†† | |
campesterol (µg/mL) | before | 7.0 ± 4.1 | 5.8 ± 1.7 |
after | 7.1 ± 4.7 | 2.1 ± 0.5**†† | |
lathosterol (µg/mL) | before | 1.2 ± 0.8 | 1.7 ± 0.7 |
after | 1.2 ± 0.8 | 3.2 ± 1.9**†† |
F/E group, fenofibrate and ezetimibe combination group; Apo, apolipoprotein; Lp(a), lipoprotein (a); LPL, Lipoprotein lipase. Values are given as mean ± SD.
P < 0.05
P < 0.01 (vs before the drug intervention); between before and after the drug intervention comparison by paired t test or Wilcoxon test
P < 0.05
P < 0.01 (vs statin group); between statin and F/E group comparison by unpaired t test or Mann-Whitney test