Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 19;7:5884. doi: 10.1038/s41598-017-06049-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The SCI-induced spasticity correlates with chronic pain. (a) Left, image of the spinal cord immediately after the lesion (white box indicates the lesion site, Th₁₁). Right, summary of the BBB (left Y axis) scaling of animal locomotion and the Ashworth rate (right Y axis) of long-lasting impairments in muscle tone on the ipsilateral side postoperatively (n = 32 SCI-injured rats, n = 14 sham-operated animals). ***P < 0.001 (two-way repeated analysis of variance and Bonferroni post-hoc test). (b) The BBB score estimated for each animal at week 1 and week 5 post-SCI (n = 32 animals) plotted against its Ashworth scoring value. The Pearson correlation coefficients (r) are indicated. (c) Left, examples of the H-reflex recordings, demonstrating the M- and the H-wave responses in control and post-SCI at ~1 month postoperatively. Right, the ratio of the H- to the-M-wave amplitudes in different experimental groups. ^### P < 0.001 (paired t-test), **p < 0.01, ***p < 0.001 (unpaired t-test). (d) The time course of changes in the thermal nociceptive threshold of the ipsilateral hindpaw in different groups of animals, demonstrating experiencing of the long-lasting pain post-SCI (n = 11 control, n = 14 sham-operated rats and n = 15 animals post-SCI). ***P < 0.001 (ANOVA with Bonferroni post-hoc test). (e) The H-reflex measurements (the H/M ratio) plotted against the thermal nociceptive threshold estimated for a respective animal at the time-point of ~1 month postoperatively for the sham-operated (n = 10 animals) and the SCI groups (n = 18 animals). The Spearman’s test significance is indicated. Green lines indicate the average parameters in control animals (no surgery). Data are expressed as mean; error bars, SEM.