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. 2017 Jul 19;7:5925. doi: 10.1038/s41598-017-06132-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression levels of CEP55 mRNA correlated inversely with overall survival in patients with pancreatic cancer. (a) Quantification analyses of CEP55 mRNA expression between 46 normal pancreas tissues and 145 primary pancreatic tumour specimens from the Oncomine database (GSE71729 specimens). (b) Quantification analyses of CEP55 mRNA expression between seven pancreatic cancer (PANC) specimens with more than 5-year survival and 51 PANC specimens with less than 5-year survival from the TCGA database. (c) Statistical correlation between the CEP55 level and 5-year survival rates in patients with PANC. (d) Kaplan-Meier analysis showing associations of overall survival with relatively high and low expressions of CEP55 mRNA. (e) Quantitative real-time reverse transcription-PCR (qRT-PCR) and western blotting detection of CEP55 mRNA and protein in normal human pancreatic nestin expressing cells (HPNE) and cultured pancreatic cancer cell lines (Panc 03.27, Capan-1, Capan-2, SW1990, HPAF-II, Panc 10.05, BxPC-3, and CFPAC-1) (left panel). The Spearman correlation coefficient was calculated to assess the significance of the association between CEP55 mRNA and its protein expression levels (right panel). *P < 0.05, **P < 0.01, ***P < 0.001.