Table 3.
Accuracy, sensitivity, and specificity of area under the receiver operating characteristic (ROC) curve (AUC) demonstrating moderate discrimination of DLB from AD
| Numerator | Denominator | AUC | Accuracy (%) | Sensitivity (%) | Specificity (%) | Threshold |
|---|---|---|---|---|---|---|
| tAD_DLB_num_1 | tDLB_specific_VOI_1 | 0.876 | 80.8 | 69.2 | 92.3 | 0.259 |
| tAD_DLB_num_2a | tDLB_specific_VOI_1a | 0.882 | 84.6 | 92.3 | 76.9 | 0.281 |
| tAD_DLB_num_1b | tAAL_PreC&Cb | 0.899 | 84.6 | 84.6 | 84.6 | 0.348 |
| tAD_DLB_num_2 | tAAL_PreC&C | 0.888 | 80.8 | 69.2 | 92.3 | 0.221 |
| tAAL_PCGc | tAAL_medOccipitalc | 0.882 | 84.6 | 76.9 | 92.3 | 0.0308 |
Values in bold indicate the highest accuracy and associated parameters
AD Alzheimer’s disease, DLB dementia with Lewy bodies, VOI volume of interest, AAL automated anatomical labeling, PCG posterior cingulate gyrus, PreC&C precuneus and cuneus
atAD_DLB_num_2/tDLB_specific_VOI_1; CISRo; CIS ratio optimized
btAD_DLB_num_1/tAAL_PreC&C: CISRmix; CIS ratio optimized and with AAL
ctAAL_PCG/tAAL_medOccipital; CISRaal; CIS ratio with AAL