Table 2.
Factors correlated with NT-proBNP levels by ANOVA.
| NT-proBNP | P-value | ||||
|---|---|---|---|---|---|
| <40 pg/mL (n = 1445) | 40 to<55 pg/mL (n = 266) | 55 to<125 pg/mL (n = 338) | ≥ 125 pg/mL (n = 91) | ||
| NT-proBNP; pg/mL | 18.5 [11.3, 27.1] | 46.9 [43.7, 50.7] | 74.9 [63.8, 88.6] | 181.4 [141.7, 298.6] | <0.001 |
| Male sex; n(%) | 1048 (72.5) | 107 (40.2) | 126 (37.3) | 51 (56.0) | <0.001 |
| Age; yrs | 48.7 ± 8 | 51.7 ± 7.7 | 52.3 ± 7.9 | 55.0 ± 8.6 | <0.001 |
| Distribution; n (%) | |||||
| <40 | 249 (17.2) | 21 (7.9) | 23 (6.8) | 5 (5.5) | <0.001 |
| 40 to 49 | 476 (32.9) | 77 (29.0) | 95 (28.1) | 18 (19,8) | |
| 50 to 59 | 605 (41.9) | 136 (51.1) | 168 (49.7) | 48 (52.8) | |
| 60 to 69 | 113 (7.8) | 28 (10.5) | 49 (14.5) | 15 (16.5) | |
| ≥70 | 2 (0.1) | 4 (1.5) | 3 (0.9) | 5 (5.5) | |
| BMI; kg/m2 | 23.1 ± 3.1 | 22.4 ± 3.4 | 22.4 ± 3.3 | 22.4 ± 3.7 | <0.001 |
| Waist circumference; cm | 81.8 ± 8.6 | 80.2 ± 9.1 | 79.8 ± 9.6 | 80.1 ± 9.0 | <0.001 |
| Obesity; n (%) | 365 (25.3) | 49 (18.4) | 67 (19.8) | 20 (22.0) | 0.030 |
| Systolic blood pressure; mm Hg | 124.9 ± 14.1 | 125.3 ± 16.6 | 128.1 ± 18.2 | 135.8 ± 21.5 | <0.001 |
| Diastolic blood pressure; mm Hg | 79.2 ± 9.8 | 77.8 ± 11.1 | 78.3 ± 12 | 82.6 ± 13.6 | 0.001 |
| Pulse pressure; mm Hg | 45.6 ± 9.6 | 47.6 ± 10.7 | 49.8 ± 11.8 | 53.2 ± 14.2 | <0.001 |
| Hypertension; n (%) | 381 (26.4) | 80 (30.1) | 119 (35.2) | 54 (59.3) | <0.001 |
| Metabolic syndrome; n (%) | 195 (13.5) | 27 (10.2) | 40 (11.8) | 16 (17.6) | 0.229 |
| Current smoking; n (%) | 553 (38.3) | 81 (30.5) | 99 (29.3) | 28 (30.8) | 0.002 |
| Total cholesterol; mg/dL | 206.2 ± 33.3 | 207.6 ± 34.8 | 202.3 ± 36.1 | 194.3 ± 34 | 0.003 |
| Triglyceride; mg/dL | 88 [62, 131] | 77 [57, 106] | 76 [54, 106] | 82 [67, 115] | <0.001 |
| HDL-cholesterol; mg/dL | 63.8 ± 16.8 | 68.8 ± 17.6 | 69.5 ± 15.7 | 66.2 ± 19 | <0.001 |
| LDL-cholesterol; mg/dL | 127.5 ± 32 | 126.2 ± 32.2 | 120.8 ± 34.1 | 114.0 ± 28.2 | <0.001 |
| Uric acid, mg/dL | 5.6 ± 1.4 | 5.1 ± 1.5 | 5.0 ± 1.5 | 5.4 ± 1.6 | <0.001 |
| Fasting blood sugar, mg/dL | 100.6 ± 16.4 | 98.7 ± 17.7 | 99.3 ± 19.5 | 104.3 ± 25.3 | 0.038 |
| eGFR; mL/min/1.73 m2 | 79.2 ± 14 | 77.3 ± 14.3 | 77.8 ± 13.6 | 75.6 ± 18.1 | 0.018 |
| Proteinuria; n (%) | 44 (3.0) | 6 (2.3) | 13 (3.9) | 10 (11.0) | <0.001 |
| Hemoglobin; g/dL | 14.6 ± 1.5 | 13.7 ± 1.5 | 13.5 ± 1.7 | 13.7 ± 1.8 | <0.001 |
| High molecular weight adiponectin; µg/mL | 5.1 [2.9, 8.6] | 7.3 [4.2, 11.1] | 7.8 [4.6, 12.4] | 6.9 [4.0, 12.2] | <0.001 |
| High sensitivity troponin T; pg/mL | 3 [3, 4] | 3 [3, 4] | 3 [3, 4] | 5 [3, 12] | <0.001 |
Data are shown as Mean ± SD, Median [IQR], or n (%).
P values were calculated by ANOVA for variables with normal distribution and chi-square test for frequency of variable. In the analysis of skewed variables, P values were calculated after transfer to logarithms by ANOVA. Abbreviations, see Table 1.