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. 2017 Jul 19;7:5814. doi: 10.1038/s41598-017-06261-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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POL improved HBV specific liver pathological conditions in HBV -transgenic mice. (A) 7 days after the 3^rd treatment, the serum of HBV -transgenic mice were collected for HBV surface antibody level by using HBV surface antibody kit. (B) 7 days after the 3^rd treatment, the serum of HBV -transgenic mice were collected for HBV surface antigen level by using HBV surface antigen kit. (C) 7 days after the 3^rd treatment, the livers of treated mice were prepared for pathological sections by HE staining. (D) 7 days after the 3^rd treatment, the livers of treated mice were prepared for HBVsAg expression by immunohistochemistry staining. Shown in each panel is 1 of at least 3 experiments with similar results. Bar, mean and SD from 3 independent experiments, each using at least three mice per group (n = 3); *p < 0.05; **p < 0.01.