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. 2017 Jul 19;7:5870. doi: 10.1038/s41598-017-05038-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered hippocampal TFCP2 and ASIC2a expression with glucose hypometabolism in patients with TLE. (a) Patient 4’s pre-surgical assessment results: magnetic resonance imaging (left) was negative, electroencephalography (middle) showed spike waves in the temporal lobe, and fluorodeoxyglucose positron emission tomography (right) revealed hypometabolic lesions in the right hippocampus. (b) Representative western blot assays of hippocampal TFCP2 and ASIC2a expression in patients with TLE (n = 13) and control patients (n = 10). β-actin was used as a loading control. (c,d) Normalised densitometry bar graphs of TFCP2 and ASIC2a for the control subjects and patients with TLE. The experiments were repeated at least 3 times. Data are presented as means ± standard errors and were analysed using unpaired t-tests. *P < 0.05, **P < 0.01 compared to controls. Uncropped western blot images are shown in Supplementary Fig. 1. Abbreviations, ASIC2a: acid-sensing ion channel 2a; TFCP2: transcription factor CP2; TLE: temporal lobe epilepsy.