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. 2017 Jul 19;7:5870. doi: 10.1038/s41598-017-05038-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered hippocampal TFCP2 and ASIC2a expression with glucose hypometabolism in pilocarpine-treated rats. (a) Representative coronal view microscopic positron emission tomography images in the different phases of epileptogenesis. (b) Hippocampal glucose uptake in the different phases after pilocarpine injection. (c) Representative western blot assays of hippocampal TFCP2 and ASIC2a expression at different post-seizure time points. (d) Bar graph showing decreased hippocampal TFCP2 expression in pilocarpine-treated rats. (e) Bar graph showing increased hippocampal ASIC2a expression in pilocarpine-treated rats. The experiments were repeated at least 3 times with at least 3 rats in each group. Data are presented as means ± standard errors and were analysed using 1-way ANOVA and Dunnett’s multiple comparisons test. *P < 0.05 compared with controls, **P < 0.01 compared with controls. Uncropped western blot images are shown in Supplementary Fig. 1. Abbreviations, ASIC2a: acid-sensing ion channel 2a; TFCP2: transcription factor CP2; SE: status epilepticus; Con: control.