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. 2017 Jul 19;7:5870. doi: 10.1038/s41598-017-05038-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TFCP2 inversely regulates ASIC2a expression. (a) Representative immunoblot and densitometric analyses showing that TFCP2 siRNA-transfected PC12 cells had 27% lower TFCP2 expression than negative siRNA-treated cells and consequently elevated ASIC2a expression. (b) Representative immunoblot and densitometric analyses showing that TFCP2 OE plasmid-transfected PC12 cells had 1.76 ± 0.45-fold greater TFCP2 expression than negative control cells and consequently suppressed ASIC2a expression. The experiments were repeated at least 3 times. Data are presented as means ± standard errors and were analysed using unpaired t-tests. *P < 0.05 compared to negative controls. Uncropped western blot images are shown in Supplementary Fig. 1. Abbreviations, ASIC2a: acid-sensing ion channel 2a; TFCP2: transcription factor CP2; siRNA: short interfering RNA; OE: overexpression; KD: knockdown; NC: negative control.