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. 2017 Jul 19;7:5870. doi: 10.1038/s41598-017-05038-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in ASIC2a expression affected the intrinsic excitability of CA1 pyramidal neurons. (a) Confocal images of CA1 pyramidal neurons expressing GFP (green) and labelled with neurobiotin (blue). Scale bar = 10 μm. (b) Representative traces of action potential firing in response to 200 pA current injections in CA1 pyramidal neurons of the negative control, ASIC2a overexpression, and ASIC2a knockdown groups, respectively. (c) Number of action potentials in CA1 pyramidal neurons from the various groups at different current injection steps. Data are presented as means ± standard errors and were analysed using 1- or 2-way ANOVA and Dunnett's multiple comparisons test. *P < 0.05, ASIC2a OE group compared with negative control group; ^#P < 0.05, ASIC2a KD group compared with negative control group. Abbreviations, ASIC2a: acid-sensing ion channel 2a; GFP: green fluorescent protein; OE: overexpression; KD: knockdown.