Table 3.
Association of relative telomere length with percent mammographic density and dense area before and after adjustment for risk factors and urinary MDA (n = 305).
| Variable | Percent Mammographic Density (square root)a | Dense Area (square root)a | Non dense area (log)a | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | p value | Beta | SE | p value | Beta | SE | p value | |
| RTL aloneb | 0.82 | 0.71 | 0.25 | 0.82 | 0.73 | 0.26 | −0.41 | 0.25 | 0.10 |
| RTL adjusted for risk factorsc | −0.32 | 0.57 | 0.58 | 0.21 | 0.75 | 0.78 | 0.05 | 0.16 | 0.77 |
| RTL adjusted for Risk Factors and MDAd | −0.44 | 0.57 | 0.44 | 0.05 | 0.75 | 0.95 | 0.07 | 0.17 | 0.66 |
| Interaction between RTL and MDAe | 3.54 | 1.06 | 0.001 | 2.82 | 1.41 | 0.05 | −1.17 | 0.31 | 0.0002 |
RTL = relative telomere length; MDA = malondialdehyde; SE = standard error.
aOutcome measure for regression analysis.
bAdjusted for PCR batch only.
cAdjusted for PCR batch and risk factors (from Table 2), except for MDA.
dAdjusted for PCR batch, risk factors and MDA.
eInteraction term for RTL*MDA, adjusted for main effects and risk factors.