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. 2017 Jul 19;7:5927. doi: 10.1038/s41598-017-05198-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Simulated dependences of AP amplitudes (Panel A), [Ca²⁺]_i transients (Panel B), and interspike intervals (Panel C) for mouse ventricular myocytes on the parameter ε during transition from WT to TNF-α overexpressing mouse ventricular myocyte. Steady-state injected current I_stim = 0.55 pA/pF. Bifurcation diagrams demonstrate steady-state, periodic activity, and bursting activity both for AP and [Ca²⁺]_i transients. AP amplitude, [Ca²⁺]_i transients, and interspike intervals were calculated in time interval from 40 to 50 s. For calculation of interspike intervals the threshold potential was set to V_th = −40 mV. I_Na with slow inactivation.