Table 3.

Associations between baseline covariates and the probability of being in the upper trajectory – multivariate class – membership models

	Model 1		Model 2
	OR (95% CI)	p value	OR (95% CI)	p value
MEN, n = 517
Age (years)	1.07 (0.98–1.16)	0.13	1.07 (0.97–1.17)	0.16
Mobility limitations	3.98 (1.54–10.28)	0.004	4.48 (1.56–12.87)	0.005
Diabetes	3.10 (1.09–8.77)	0.03	3.50 (1.13–10.87)	0.03
BMI: obese or over-weighted	1.37 (0.56–3.36)	0.49	1.11 (0.43–2.87)	0.83
Ischemic pathologies	2.01 (0.79–5.10)	0.14	2.91 (1.03–8.26)	0.04
5-HTTLPR polymorphism: S allele	0.46 (0.19–1.13)	0.09	0.63 (0.24–1.65)	0.35
Recent stressful life event			4.50 (1.09–18.50)	0.04
Adverse childhood event			1.39 (0.49–3.93)	0.53
Parental mental problems			2.96 (0.88–9.93)	0.08
Lack of support during childhood			2.48 (0.81–7.59)	0.11
WOMEN, n = 736
Age (years)	1.00 (0.96–1.04)	0.99	1.02 (0.96–1.08)	0.59
Mobility limitations	4.54 (2.23–9.24)	<0.0001	4.95 (2.30–10.68)	<0.0001
Diabetes	2.16 (0.79–5.94)	0.13	2.24 (0.71–7.03)	0.17
BMI: obese or over-weighted	0.97 (0.56–1.68)	0.91	0.87 (0.47–1.63)	0.67
Ischemic pathologies	3.06 (1.11–8.38)	0.03	3.14 (1.00–9.86)	0.05
Cognitive impairment	1.60 (0.86–2.97)	0.14	1.47 (0.77–2.83)	0.25
Recent stressful life event			3.16 (1.62–6.17)	0.0008
Adverse childhood event			3.09 (1.64–5.81)	0.0005
Parental mental problems			2.52 (1.15–5.52)	0.02
Lack of support during childhood			1.57 (0.72–3.41)	0.25

BMI, body mass index; CI, confidence Interval; OR, odds ratio.