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. 2017 Jul 19;7:5895. doi: 10.1038/s41598-017-06247-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In PCAECs pre-treated with the TRPC3 selective blocker Pyr3 or transfected with TRPC3 specific siRNA, both IK_Ca and SK_Ca currents in response to bradykinin (BK) were significantly inhibited. (a) Representative traces and current-voltage relationship of whole-cell K⁺ current in PCAECs from different treatment groups before and after BK stimulation with further application of the IK_Ca channel blocker TRAM-34 and the SK_Ca channel blocker apamin. *p < 0.05, **p < 0.01, BK vs. basal; ^#p < 0.05, ^##p < 0.01, BK + TRAM-34 vs. BK; ^{^}p < 0.05, ^{^^}p < 0.01, BK + TRAM-34 + Apamin vs. BK + TRAM-34. (b) Summarized data of BK-induced IK_Ca and SK_Ca currents from 5 independent experiments, each obtained from cell isolates of different heart. *p < 0.05, **p < 0.01, ***p < 0.001, one-way ANOVA and Scheffe post-hoc test.