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. 2017 Jul 19;7:5895. doi: 10.1038/s41598-017-06247-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TRPC3 channels play an important role in EDHF-mediated relaxation in porcine small coronary arteries (a, n = 8 in each group). H-R exposure impairs the EDHF-mediated vasorelaxation and activation of TRPC3 preserves the EDHF-type response under H-R condition (b, n = 8 in each group). The EDHF-response was induced by bradykinin in the presence of indomethacin, N^G-nitro-L-arginine, and oxyhemoglobin. *p < 0.05, **p < 0.01 vs. control; ^#p < 0.05, ^##p < 0.01 vs. H-R, unpaired t test (a), one-way ANOVA and Scheffe post-hoc test (b). Pyr3: TRPC3 selective blocker. OAG: TRPC3/6/7 activator.