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. 2017 Jul 19;7:5801. doi: 10.1038/s41598-017-06374-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased activity of Pcdh19 mutant mice in the second open field test. (a–d) Test with male mice. (e–h) Test with female mice. Total distance (a,e), vertical activity (b,f), time spent in the center of box (c,g), and count of stereotypic activity (d,h) were measured. Pcdh19 hemizygous males showed significantly increased stereotypic counts, whereas Pcdh19 heterozygous females showed significantly increased time spent in the center of the box compared to wild-type counterparts.