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. 2017 Jul 19;7:5824. doi: 10.1038/s41598-017-05163-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RARα antagonists reduce ApoC-III inhibition by RAR agonist. Hep3B cells were pretreated with various RARα antagonists 2 hrs before RAR agonist stimulation; cells were then incubated for 3 days and secreted ApoC-III protein levels were measured using the ApoC-III HTRF assay. (a) LGD1550 co-treated with 10 nM of BMS493, an RAR pan antagonist. (b) LGD1550 co-treated with 50 nM of BMS614, an RARα specific antagonist. (c) LGD1550 with 100 nM of MM11253, a specific RARγ agonist. (d) RARα in Hep3B cells were silenced by transient transfection with siRNA. Cells with or without siRARα were stimulated with 1 μM of LGD1550 and ApoC-III levels were measured after 3-day incubation. Representative triplicate data is shown from at least three independent experiments.